Innenrücktitelbild: A Caged In‐Source Laser‐Cleavable MALDI Matrix with High Vacuum Stability for Extended MALDI‐MS Imaging (Angew. Chem. 22/2023)

Some matrix chemicals used in MALDI mass spectrometry are not sufficiently vacuum-stable and therefore suitable for extended imaging experiments. Caging the matrices by covalent attachment of a photocleavable group renders them vacuum-stable, as reported Qiuqin Zhou et al. their Research Article (e202217047). The caged is eventually uncaged situ UV laser ion source. Thereby, original liberated, thus enabling large clinical or pharmacological sample cohorts. Artwork Miriam Rittel, Stefano Rizzo, Silas Ackermann.